Map - Hopkins County, Kentucky (Hopkins County)

Hopkins County is a county located in the western part of the U.S. state of Kentucky. As of the 2020 census, the population was 45,423. Its county seat is Madisonville. Hopkins County was created December 9, 1806 from Henderson County. It was named for General Samuel Hopkins, an officer in both the American Revolutionary War and War of 1812, and later a Kentucky legislator and U.S. Congressman.

The Madisonville, Kentucky Micropolitan Statistical Area includes all of Hopkins County.

The topography ranges from flatlands along the broad river valleys of the Pond River, Tradewater River, and Green River, to hilly and rolling land in the southern and central parts of the county. Coal mines operate in the southern part of Hopkins County and agriculture is a mainstay in the northern part. Major crops are soybeans, corn, and tobacco. Along with coal, resources include oil and natural gas.

The earliest inhabitants were prehistoric Native Americans who lived, hunted, and farmed in the region. One of their settlements was a rough stone structure on Fort Ridge, which has since been destroyed by strip mining for coal. Some of the early settlers were Revolutionary War veterans who received land grants for their service from Virginia in the area southwest of the Green River. Among these was Baron Von Steuben, a Prussian officer who had trained George Washington's Continental Army at Valley Forge during the winter of 1776–77. He had received a grant of several thousand acres in the northwest part of the county. According to tradition, Von Steuben was wounded in an Indian attack on his first visit to Kentucky. He then quit-claimed his property. Nevertheless, a salt spring on his grant came to be known as Steuben's Lick. By the 1880s, the community that grew up around the lick was known as Manitou.

Roads in the county often followed animal trails that led to salt and mineral springs. The major traces were those which connected the county seat at Madisonville with Henderson to the north, Hopkinsville to the south, and Russellville to the southeast. Numerous other trails led to the mills and ferries on the Pond and Tradewater Rivers and their tributaries.

On January 3, 1829, Ashbyburg in the northeastern part of the county was incorporated. Located on the Green River, it thrived as a steamboat landing during the 19th century. Other antebellum communities included Nebo, Kentucky, northwest of Madisonville, and Charleston, Kentucky, named after "Free Charles," a black freedman who operated a tavern in the southwest part of the county.

Hopkins County was divided by the American Civil War. Union supporters joined the 35th Kentucky Infantry (Mounted), a regiment recruited locally in late 1863 by James M. Shackelford, while in 1862 Adam Rankin Johnson had recruited Confederate troops for his 10th Kentucky Cavalry Regiment. The courthouse in Madisonville was burned by Kentucky Confederates led by Gen. Hylan Benton Lyon on December 17, 1864, as they passed through western Kentucky, since it was being used to house Union soldiers.

However, the harsh policies imposed by the occupying Union armies caused much resentment and served to increase the sympathy for the Confederate cause. Because of that, the majority of the white population voted for the Democratic Party well into the 20th century.

Farming was the major occupation in Hopkins County for most of the 19th century, with tobacco the leading crop. Around 1837 local blacksmith James Woolfolk found an outcropping of coal on his land.